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In general, you take the model size in billions of parameters (eg: 397B), divide it by 2 and add a bit for overhead, and that’s how much RAM/VRAM it takes to run it at a “normal” quantization level. For Qwen3.5-397B, that’s about 220 GB. Ideally that would be all VRAM for speed, but you can offload some or all of that to normal RAM on the CPU, you’ll just take a speed hit.
So for something like Qwen3.5-397B, it takes a pretty serious system, especially if you’re trying to do it all in VRAM.