I recommend going with Virt-manager, it works much better than VirtualBox in my experience.
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The reason for better performance is that virt-manager (KVM actually under the hood) is a type 1 hypervisor while virtualbox is a type 2 hypervisor.
For a gui to qemu use Virt-manager or gnome boxes.
iirc gnome boxes doesnt support gpu passthrough while virt-manager does, which would be convenient to have for adobe apps.
Boxes supports it on Linux hosts
What? It sorta gpu passthrough? I couldn’t find any way to enable it online
GPU acceleration. You don't want GPU passthough as then you have 2 cursors and no copy and paste
I used VMware or vbox for 10+ years, or HyperV in Windows.
Lastly in Linux I needed a windows XP install for an old program, I tried QEMU and after booting the install iso, I just created a small script to launch my installed image with some parameters I needed for serial port, and that's it.
I like QEMU, and will try to use it for any VM now.
Make sure you use KVM for acceleration.
Best option is virtual manager
You've already decided, so just go for it.
Just another recommendation for QEMU + Virtmanager. I've been using that setup for some time now and its a smooth and responsive experience.
I did have some issues getting USB redirection on EndeavourOS, the virtualization entry on the Arch wiki helped. Check out section 8, SPICE. I didn't have the same problem in Manjaro, so it appears to be just a missing package/configuration issue with more minimalist Arch-based distros.
You'll probably start with virt-manager then move to proxmox. This is the way, it's only a matter of how long before you realize it's better.
Both work. But for desktop use I recommend VirtualBox.