Just for some real-world comparison, I set up a new NAS earlier this year using a rackserver, SAS cards, and eight 18TB HDDs configured like RAID6 (actually using zfs-z2). I played with a few different configurations but ultimately my write speeds reached around 480MB/s because of the parallel access to so many drives. Single drive access was of course quite a bit slower. Because of this testing I knew I could use cheap SATA2 backplanes without affecting the performance.
So basically, do a lot of testing with your planned hardware to get the best throughput, but a single HDD is going to be your single biggest bottleneck in anything you set up.