It's not Let's Encrypt, but I've been happy with this Cloudflare-flavored ACME through Caddy.
https://github.com/CaddyBuilds/caddy-cloudflare
I really only use it for my local-hosted stuff that I don't expose to the web. So, when I'm at home, https://radarr/.[mydomain].com resolves to 192.168.1.145:7878. That sort of thing...