For me, the problem is "isometric". There have been very few games like that I've finished compared to others. It feels artificially constrained, especially in a 3D environment, when visibility is limited to like <10 meters away from your character. It's worse if the camera rotates because then I find it quite hard to make a mental map.
I don't have this issue with a top-down perspective generally. Maybe those tend to be more 2D (even if rendered they can't really include environmental verticality) so it's easier to navigate.
I do find it's a barrier for some fairly modern games I want to play like Divinity Original Sin 1+2 and Disco Elysium. I wish that wasn't the case...