It may mean the user doesn't think their use is similar enough to the people who make the distro/DE, or trust the distro makers' decision making ability.
If a distros' makers think snaps are a good idea, or that the distro shouldn't by default show available security updates, or have a UI that hides how many open instances there are of a program unless you hover over an icon, or hides the titles of those open programs, or hides panels; then the way I use a PC is too different from the way they do - and there are likely more things in the background that we disagree with which can't as easily be changed like UI settings.
The CDC says they're not, they just rarely have rabies: https://www.cdc.gov/vitalsigns/rabies/pdf/vs-0612-wildlife-rabies-h.pdf