Well, it all comes down to distro when it comes to package selections and availability.
I can say though that in the last year or so I have found 100% of the software I needed in the repositories and that includes at least a dozen proprietary applications ( including some that require registration and / or licensing such as Burp Suite Pro and JetBrains Rider ).
Everything I have installed came to me in the same package format ( or was automatically converted to it by the package management tooling - all the same to me ). A single command updates everything.
That is without resorting to Flatpak which I am sure provides a pretty good selection to other distros as well ( at the cost of a second package format ).
How do you like LMDE vs regular Mint?