Is this launching games through Steam? I had a similar issue launching games through Steam using gamescope and had to set some launch options. Unfortunately I am at work and can't remember what those launch options are but when I get back home I will add them.
Edit launch options: LD_PRELOAD="" gamescope -ef -W 3840 -H 2160 -r 144 --hdr-enabled --adaptive-sync --mangoapp -- gamemoderun %command%
As others have mentioned I think it was the "LD_PRELOAD=" that actually fixed the issue
Low power server in a friends basement running syncthing