Immutable was the only thing that got me to switch back from QubesOS on my desktop. I was doing Qubes with a win10 HVM with my 3070 passed through and it was a couple frames off from native performance. Still keep Qubes on my T480 for infra specific work but my "dev" machine with no creds is the desktop now.
Couldn't get the performance quite right for a Linux based HVM and was wanting the HW accel for some of my work (CAD, figma) so I loaded Bazzite with KDE which runs Fedora Atomic and it's been amazing for both gaming and work.
Distrobox with boxbuddy and rootful containers where needed has been extremely pleasant and they all live as a subdirectory of my home with a ZSH install script I have to load the terminal styles I want into any new containers. Any apps you install in the container you can export to your start menu and launch seamlessly without tainting your host with any weird dependencies you might need for a project.
We use ddev a lot so needed a rootful container for Docker but other projects I just treat like a VM almost (R projects for instance), install whats needed to get an env going real quick and fire up the IDE in the container and get to work.
EVERYTING I care about is in /var, including my home which makes backups and snapshots stupid simple which I love coming from a traditional Linux distro
If you've used it in the past it's MUCH better now but there are still hiccups and certain apps you have to force to use X but they do typically run well still, at least the ones I've encountered