They only list support for Windows and MacOS on their site. The answer is almost certainly no, it doesn't work with Linux. People may reverse engineer it like they did with the Stream Deck or GoXLR devices, but don't hold your breath. Your best alternative would be something like this: https://drop.com/buy/megalodon-doio-hot-swappable-rgb-30-keyboard?defaultSelectionIds=970727
EDIT: Or, you could build your own without the need of a raspberry pi using something like this: https://www.instructables.com/STREAM-DECK-KILLER-and-OpenSource/
The main thing I have learned after switching to Linux full-time is that weird, proprietary hardware like this is almost never a good idea, for many reasons. It's very easy to make labels for keys if you really want to, and if you need more functionality, having more buttons instead of layers is always going to be faster to learn and use. Especially if you are trying to use this as a home automation interface, it's probably a better idea to have either a touch screen or a separate screen and keypad.
Sure, this thing looks nice, but in a couple years (at most) it will be e-waste.