You could save some.
With that said, if you're short on cash and you're contemplating whether you can afford a Framework by saving on these parts, you might be able to save a lot more by getting an off-lease ThinkPad, Latitude or even B-stock Framework. For example I just got a Latitude 7400 yesterday for $250. It's got 16GB of RAM and a 500GB SSD.
Oooh yes, let's throw some mud in the gaping holes of this packaging solution, spit and tape the rest to make it do something it was not designed to do. Brilliant idea! ☺️