this post was submitted on 02 Jan 2024
1237 points (98.3% liked)
Technology
59534 readers
3195 users here now
This is a most excellent place for technology news and articles.
Our Rules
- Follow the lemmy.world rules.
- Only tech related content.
- Be excellent to each another!
- Mod approved content bots can post up to 10 articles per day.
- Threads asking for personal tech support may be deleted.
- Politics threads may be removed.
- No memes allowed as posts, OK to post as comments.
- Only approved bots from the list below, to ask if your bot can be added please contact us.
- Check for duplicates before posting, duplicates may be removed
Approved Bots
founded 1 year ago
MODERATORS
you are viewing a single comment's thread
view the rest of the comments
view the rest of the comments
If it's based off mutated dna do they have to tailor a vaccine to each case? Or do cells mutate the same way every time?
They have to manufacture it unique to the individual. Luckily, manufacturing custom mRNA is not very expensive.
That's really cool that they can do that. Kind of reminds me of something out of Star Trek when they have to "synthesize a cure" or whatever for some space disease.
Especially compared to normal cancer treatment
In general, mutations can happen anywhere on any gene, so every patient's cancer will have its unique signature of mutations. However, like in the evolution of organisms by natural selection, most random mutations will have a detrimental effect and the cells carrying it will die. Some of the mutations will be neutral and despite the change in the amino acid, the cells harbouring it won't survive better or worse than cells that don't have it. But a few mutations will make the cancer cells proliferate faster or evade the immune system better, which will lead to these cells surviving and ultimately overtaking the population of the cancer cells. The latter mutations often happen in the same places on the same genes, and in melanoma for example, in as many as 41% of cases the 600th amino acid in a protein called BRAF mutates from valine to alanine (so the code for that mutation is "BRAF V600E"), and BRAF is only one example of such genes that commonly mutate in the same position.
So to answer your question - I don't know Moderna's exact protocol, but my guess is that the tailored vaccine will contain a mixture of these commonly occurring mutations and some mutations that are unique to the patient.