A few years ago I replaced Photoshop with Affinity. Affinity's user interface is pretty awful, even compared to Photoshop, but it does at least run a bit better. A few years ago I switched from premiere pro to da Vinci resolve, and though resolve has a bit of a learning curve, overall I think it's better than premiere - it's definitely faster and crashes a lot less.
I'm hoping that audacity 4 is a good enough audio editor to replace audition - we'll see, audition is actually pretty good imo but I'd accept a slight downgrade if it means I can get away from Adobe entirely.